E-patients are at the center of the health care revolution, marching forward with or without the help of industry leaders. They are the worried well using search engines to look up basic advice. They are the chronically ill using discussion forums to trade in-depth knowledge. Or as one e-patient wrote in one of our online surveys, "we are lab rats tapping out messages on the bars of our cages." But how will Health 2.0 attract and serve the majority, not just the elite?

A linked version of these remarks is available at e-patients.net, as are video clips.